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Effect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients

Zifman Eyal, Zevit Noam, Heshin-Bekenstein Merav, Turner Dan, Shamir Raanan, Silbermintz Ari,
소속 상세정보
 ( Zifman Eyal ) - Schneider Children’s Medical Center of Israel Institute of Gastroenterology, Nutrition and Liver Diseases
 ( Zevit Noam ) - Schneider Children’s Medical Center of Israel Institute of Gastroenterology, Nutrition and Liver Diseases
 ( Heshin-Bekenstein Merav ) - Shaare Zedek Medical Center Department of Pediatric
 ( Turner Dan ) - Hebrew University of Jerusalem Shaare Zedek Medical Center Pediatric Gastroenterology Institute
 ( Shamir Raanan ) - Schneider Children’s Medical Center of Israel Institute of Gastroenterology, Nutrition and Liver Diseases
 ( Silbermintz Ari ) - Schneider Children’s Medical Center of Israel Institute of Gastroenterology, Nutrition and Liver Diseases

Abstract


Purpose: To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects.

Methods: We retrospectively evaluated pediatric CD subjects in serological remission who were previously immunized for hepatitis B virus as infants. The temporal relationship between HBsAb concentration, the amount of time on a GFD, and age were evaluated.

Results: Overall, 373 CD subjects were analyzed: 156 with HBsAb sampled prior to GFD initiation and 217 after initiation of a GFD and in serological remission. Median age at HBsAb concentration measurement for those before and after GFD initiation was 5.3 years (interquartile range [IQR], 3.1?9.2 years) and 7.6 years (IQR, 5.4?10.9 years), respectively (p<0.001). There was no sex difference between the groups. The median time of HBsAb measurement was 2 months (IQR, 0?5.7 months) before and 12.8 months (IQR, 5.3?30.3 months) after initiation of GFD. The HBsAb concentration was low in 79 (50.6%) and 121 (55.7%) subjects before and after GFD initiation, respectively (p=0.350). Age was inversely associated with low HBsAb concentrations. Neither being on a GFD nor sex was associated with low HBsAb concentrations.

Conclusion: Adherence to a GFD does not affect HBsAb concentration in children with CD. Age is inversely associated with HBsAb concentration.

키워드

Antibodies; Immunization; Serology; Child

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