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Cow's Milk-Related Symptom Score in Presumed Healthy Polish Infants Aged 0?6 Months

Bigorajska Karolina, Filipiak Zuzanna, Winiarska Paulina, Adamiec Anita, Trent Bogumiła, Vandenplas Yvan, Ruszczynski Marek, Szajewska Hania,
소속 상세정보
 ( Bigorajska Karolina ) - Medical University of Warsaw Department of Pediatrics
 ( Filipiak Zuzanna ) - Medical University of Warsaw Department of Pediatrics
 ( Winiarska Paulina ) - Medical University of Warsaw Department of Pediatrics
 ( Adamiec Anita ) - Medical University of Warsaw Department of Pediatrics
 ( Trent Bogumiła ) - St. Hedwig Hospital in Trzebnica Department of Paediatric
 ( Vandenplas Yvan ) - Vrije Universiteit Brussel Universitair Ziekenhuis Brussel Kidz Health Castle
 ( Ruszczynski Marek ) - Medical University of Warsaw Department of Pediatrics
 ( Szajewska Hania ) - Medical University of Warsaw Department of Pediatrics

Abstract


Purpose: The Cow's Milk-related Symptom Score (CoMiSS™), which considers crying, regurgitation, stools, skin and respiratory symptoms, was developed as an awareness tool for evaluating cow's milk-related symptoms. The scoring ranges from 0 to 33. A score ≥12 was proposed as being likely cow's milk-related and suggestive of allergy to cow's milk. This study aimed to determine the age-related CoMiSS™ values in presumed healthy infants in Poland.

Methods: This was a cross-sectional study conducted in well-child clinics in two locations. Parents of the presumed healthy infants aged ≤6 months were approached during a routine checkup/vaccination visit. The exclusion criteria were as follows: presence of acute or chronic diseases, preterm delivery, treatment with therapeutic formula, and use of any food supplements (except vitamins) or medications.

Results: Data from 226 infants were obtained (median age [Q1?Q3], 4 months [3?4]). The overall median (Q1?Q3) and mean (standard deviation) CoMiSS™ values were 4 (2?7) and 4.7 (3.5), respectively. The 95th percentile was 11. Scores on some, albeit not all, components of the CoMiSS™ significantly differed between age groups (crying, stools) or feeding type groups (stools and skin symptoms). Eleven children (4.9%) scored ≥12.

Conclusion: This study adds to earlier age-related CoMiSS™ data by providing CoMiSS™ values in presumed healthy infants in Poland.

키워드

Infant; Milk; Food allergy; Food hypersensitivity

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