잠시만 기다려 주세요. 로딩중입니다.

Nationwide Multicenter Study of Eosinophilic Esophagitis in Korean Children

이건송, 최병호, 강빈, 김승, 김재영, 심정옥, 이유민, 이은혜, Jang Hyo-Jeong, Ryoo Eell, 양혜란,
소속 상세정보
이건송 ( Lee Kun-Song ) - Dankook University College of Medicine Department of Pediatrics
최병호 ( Choe Byung-Ho ) - Kyungpook National University School of Medicine Department of Pediatrics
강빈 ( Kang Ben ) - Kyungpook National University School of Medicine Department of Pediatrics
김승 ( Kim Seung ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
김재영 ( Kim Jae-Young ) - Gyeongsang National University Changwon Hospital Department of Pediatrics
심정옥 ( Shim Jung-Ok ) - Korea University Guro Hospital Department of Pediatrics
이유민 ( Lee Yoo-Min ) - Soonchunhyang University Bucheon Hospital Department of Pediatrics
이은혜 ( Lee Eun-Hye ) - Eulji University School of Medicine Nowon Eulji Medical Center Department of Pediatrics
 ( Jang Hyo-Jeong ) - Keimyung University School of Medicine Department of Pediatrics
 ( Ryoo Eell ) - Gachon University Gil Medical Center Department of Pediatrics
양혜란 ( Yang Hye-Ran ) - Seoul National University Bundang Hospital Department of Pediatrics

Abstract


Purpose: In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children.

Methods: A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. EoE was diagnosed according to diagnostic guidelines and EGEIE was diagnosed when there were >15 eosinophils in the esophagus per high power field (HPF) and >20 eosinophils per HPF deposited in the stomach and duodenum with abnormal endoscopic findings.

Results: Of the 910 subjects, 14 (1.5%) were diagnosed with EoE and 12 (1.3%) were diagnosed with EGEIE. Vomiting was the most common symptom in 57.1% and 66.7% of patients with EoE and EGEIE, respectively. Only diarrhea was significantly different between EoE and EGEIE (p=0.033). In total, 61.5% of patients had allergic diseases. Exudates were the most common endoscopic findings in EoE and there were no esophageal strictures in both groups. The median age of patients with normal endoscopic findings was significantly younger at 3.2 years, compared to the median age of 11.1 years in those with abnormal endoscopic findings (p=0.004).

Conclusion: The incidence of EoE in Korean children was lower than that of Western countries, while the incidence of EGEIE was similar to EoE. There were no clinical differences except for diarrhea and no differences in endoscopic findings between EoE and EGEIE.

키워드

Eosinophilic esophagitis; Eosinophilic gastroenteritis; Incidence; Child

원문 및 링크아웃 정보

 

등재저널 정보