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Histopathological Variants of Hepatocellular Carcinomas: an Update According to the 5th Edition of the WHO Classification of Digestive System Tumors

대한간암학회지 2020년 20권 1호 p.17 ~ 24
김해령, 장미, 박영년,
소속 상세정보
김해령 ( Kim Hae-Ryoung ) - Seoul National University College of Medicine Seoul National University Hospital Department of Pathology
장미 ( Jang Mi ) - Yonsei University College of Medicine Department of Pathology
박영년 ( Park Young-Nyun ) - Yonsei University College of Medicine Department of Pathology

Abstract


Hepatocellular carcinoma (HCC) is heterogeneous in pathogenesis, phenotype and biological behavior. Various histopathological features of HCC had been sporadically described, and with the identification of common molecular alterations of HCC and its genomic landscape over the last decade, morpho-molecular correlation of HCC has become possible. As a result, up to 35% of HCCs can now be classified into histopathological variants, many of which have unique molecular characteristics. This review will provide an introduction to the variously described histopathological variants of HCC in the updated WHO Classification of Digestive System Tumors.

키워드

Classification; Hepatocellular carcinoma; Pathology

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