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Hepatocellular Carcinoma in Korea Between 2008 and 2011: an Analysis of Korean Nationwide Cancer Registry

대한간암학회지 2020년 20권 1호 p.41 ~ 52
윤준식, 이한아, 박준용, 김보현, 이인준, 전영은, 홍석균, 이동현, 공현주, 원영주, 김은양, 이정훈,
소속 상세정보
윤준식 ( Yoon Jun-Sik ) - Inje University College of Medicine Busan Paik Hospital Department of Internal Medicine
이한아 ( Lee Han-Ah ) - Korea University College of Medicine Department of Internal Medicine
박준용 ( Park Jun-Yong ) - Yonsei University College of Medicine Department of Internal Medicine
김보현 ( Kim Bo-Hyun ) - National Cancer Center Center for Liver Cancer
이인준 ( Lee In-Joon ) - National Cancer Center Department of Radiology
전영은 ( Chon Young-Eun ) - CHA University CHA Bundang Medical Center Department of Internal Medicine
홍석균 ( Hong Suk-Kyun ) - Seoul National University College of Medicine Department of Surgery
이동현 ( Lee Dong-Hyeon ) - Seoul Metropolitan Government Seoul National University Boramae Medical Center Department of Internal Medicine
공현주 ( Kong Hyun-Joo ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
원영주 ( Won Young-Joo ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
김은양 ( Kim Eun-Yang ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
이정훈 ( Lee Jeong-Hoon ) - Seoul National University College of Medicine Department of Internal Medicine

Abstract


Backgrounds/Aims: Backgrounds/Aims: In Korea, hepatocellular carcinoma (HCC) is the sixth most common cancer and results in the second-highest cancer death rate among all cancers. We aimed to describe the characteristics of patients who were newly diagnosed with HCC in Korea between 2008 and 2011.

Methods: The Korean Primary Liver Cancer Registry (KPLCR) is a random sample consisting of approximately 15% of patients with newly diagnosed primary liver cancer registered in the Korean Central Cancer Registry. We investigated the baseline characteristics, treatment modalities, and overall survival (OS) of patients with HCC registered in the KPLCR between 2008 and 2011.

Results: A total of 6,083 patients were histologically or radiologically diagnosed with HCC. The hepatitis B virus was the predominant HCC etiology (72.0%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system, stages 0, A, B, C, and D accounted for 8.6%, 39.7%, 11.5%, 33.8%, and 6.9%, respectively. Transarterial therapy (41.7%) was the most commonly performed initial treatment, followed by best supportive care (21.7%), surgical resection (16.7%), and local ablation therapies (10.6%). The overall rate of adherence to the BCLC treatment guideline was only 37.7%. The 1-, 3-, and 5-year OS rates were 65.6%, 46.2%, and 36.8%, respectively.

Conclusions: Between 2008 and 2011, approximately half of patients with HCC (48.3%) were candidates for curative treatment (BCLC stage 0 or A), but one-third of patients (33.8%) had advanced HCC (BCLC stage C). Transarterial therapy was the most commonly conducted initial treatment and the 5-year OS rate was 36.8% in this period.

키워드

Hepatocellular carcinoma; Epidemiology; Overall survival; Hepatitis B; Korea

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