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Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review

대한간암학회지 2020년 20권 1호 p.67 ~ 71
임대현, 유재훈, 전대원, 이오영, 윤병철, 이항락, 김경수, 최호순,
소속 상세정보
임대현 ( Lim Dae-Hyun ) - Hanyang University College of Medicine Department of Internal Medicine
유재훈 ( Yoo Jai-Hoon ) - Hanyang University College of Medicine Department of Internal Medicine
전대원 ( Jun Dae-Won ) - Hanyang University College of Medicine Department of Internal Medicine
이오영 ( Lee Oh-Young ) - Hanyang University College of Medicine Department of Internal Medicine
윤병철 ( Yoon Byung-Chul ) - Hanyang University College of Medicine Department of Internal Medicine
이항락 ( Lee Hang-Rak ) - Hanyang University College of Medicine Department of Internal Medicine
김경수 ( Kim Kyung-Soo ) - Hanyang University College of Medicine Department of Internal Medicine
최호순 ( Choi Ho-Soon ) - Hanyang University College of Medicine Department of Internal Medicine

Abstract


Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment.

키워드

Sorafenib; Coronary artery vasospasm; Variant angina; Tyrosine kinase inhibitor; Vascular endothelial growth factor inhibitor

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