잠시만 기다려 주세요. 로딩중입니다.

Infiltration of T Cells and Programmed Cell Death Ligand 1-expressing Macrophages as a Potential Predictor of Lenvatinib Response in Hepatocellular Carcinoma

대한간암학회지 2020년 20권 2호 p.128 ~ 134
성필수, 조성우, 이재준, Yang Hyun, 장정원, 배시현, 최종영, 윤승규,
소속 상세정보
성필수 ( Sung Pil-Soo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
조성우 ( Cho Sung-Woo ) - Catholic University College of Medicine Catholic University Liver Research Center
이재준 ( Lee Jae-Jun ) - Catholic University College of Medicine Eunpyeong St. Mary’s Hospital Department of Internal Medicine
 ( Yang Hyun ) - Catholic University College of Medicine Eunpyeong St. Mary’s Hospital Department of Internal Medicine
장정원 ( Jang Jeong-Won ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
배시현 ( Bae Si-Hyun ) - Catholic University College of Medicine Eunpyeong St. Mary’s Hospital Department of Internal Medicine
최종영 ( Choi Jong-Young ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
윤승규 ( Yoon Seung-Kew ) - Catholic University College of Medicine Eunpyeong St. Mary’s Hospital Department of Internal Medicine

Abstract


Background/Aims: Lenvatinib was recently proven to be non-inferior to sorafenib in treating unresectable hepatocellular carcinoma (HCC) in a phase-3 randomized controlled trial. In this study, we investigated whether the response to lenvatinib was affected by tumor immunogenicity.

Methods: Between May 2019 and April 2020, nine patients with intermediate-to-advanced HCC, who were treated with lenvatinib after liver biopsy, were enrolled. Immunohistochemical staining and multi-color flow cytometry were performed on specimens obtained from liver biopsy.

Results: Among the nine patients enrolled, four showed objective responses (complete responses+partial responses). Immunohistochemical staining for CD3, CD68, and programmed cell death ligand 1 (PD-L1) demonstrated that patients with objective responses showed marked infiltration of T cells and PD-L1-expressing macrophages in intra-tumoral and peri-tumoral tissues compared to those without objective responses. A significant difference in the numbers of infiltrated T cells, both in the intra-tumoral (P<0.01) and peri-tumoral regions (P<0.05), were identified between responders and non-responders. Regarding the number of infiltrated macrophages, no significant difference was found between the responders and non-responders, although the number of PD-L1-expressing tumor-associated macrophages was significantly higher in responders than that in non-responders (P<0.05).

Conclusions: Tumor immunogenicity, as indicated by T cell and PD-L1-positive macrophage infiltration, affects lenvatinib response in unresectable HCC.

키워드

Hepatocellular carcinoma; Lenvatinib; PD-L1; Tumor-associated macrophage; Objective response

원문 및 링크아웃 정보

등재저널 정보