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Hepatocellular Carcinoma in Korea between 2012 and 2014: an Analysis of Data from the Korean Nationwide Cancer Registry

대한간암학회지 2020년 20권 2호 p.135 ~ 147
전영은, 이한아, 윤준식, 박준용, 김보현, 이인준, 홍석균, 이동현, 공현주, 김은양, 원영주, 이정훈,
소속 상세정보
전영은 ( Chon Young-Eun ) - CHA University CHA Bundang Medical Center Department of Internal Medicine
이한아 ( Lee Han-Ah ) - Korea University College of Medicine Department of Internal Medicine
윤준식 ( Yoon Jun-Sik ) - Inje University College of Medicine Busan Paik Hospital Department of Internal Medicine
박준용 ( Park Jun-Yong ) - Yonsei University College of Medicine Department of Internal Medicine
김보현 ( Kim Bo-Hyun ) - National Cancer Center Research Institute and Hospital Center for Liver Cancer
이인준 ( Lee In-Joon ) - National Cancer Center Department of Radiology
홍석균 ( Hong Suk-Kyun ) - Seoul National University College of Medicine Department of Surgery
이동현 ( Lee Dong-Hyeon ) - Seoul Metropolitan Government Seoul National University Boramae Medical Center Department of Internal Medicine
공현주 ( Kong Hyun-Joo ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
김은양 ( Kim Eun-Yang ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
원영주 ( Won Young-Joo ) - National Cancer Center National Cancer Control Institute Cancer Registration and Statistics Branch
이정훈 ( Lee Jeong-Hoon ) - Seoul National University College of Medicine Department of Internal Medicine

Abstract


Background/Aims: Considering the high prevalence and mortality of hepatocellular carcinoma (HCC) in Korea, accurate statistics for HCC are important. We evaluated the characteristics of Korean patients with newly diagnosed HCC.

Methods: We retrospectively evaluated data from the Korean Primary Liver Cancer Registry (KPLCR). The baseline characteristics, treatment modalities, and overall survival (OS) of 4,572 patients with HCC registered in the KPLCR between 2012 and 2014 were investigated.

Results: At the time of HCC diagnosis, the median age was 60.0 years, with male predominance (79.6%). Hepatitis B virus infection was the most common etiology (59.1%). The rates of Barcelona Clinic Liver Cancer (BCLC) stages 0, A, B, C, and D at diagnosis were 3.9%, 36.9%, 12.5%, 39.4%, and 7.3%, respectively. The proportion of very early or early stage HCC at diagnosis (BCLC stage 0 or A) in the 2012?2014 cohort was significantly lower than that in the 2008?2011 cohort (40.8% vs. 48.3%, P<0.001). Transarterial therapy (37.5%) was the most commonly performed initial treatment, followed by surgical resection (19.8%), best supportive care (19.1%), and local ablation (10.6%). The median OS was 2.9 years, and the 1-, 3-, and 5-year OS rates were 67.7%, 49.3% and 41.9%, respectively. The OS rate of the 2012?2014 cohort was significantly higher than that of the 2008?2011 cohort (log-rank, P<0.001).

Conclusions: The OS of HCC patients registered in the KPLCR between 2012 and 2014 significantly improved. Nevertheless, as about half of the HCC patients were diagnosed at an advanced stage, vigorous and optimized HCC screening strategies should be implemented.

키워드

Epidemiology; Hepatocellular carcinoma; Hepatitis B; Korea; Survival

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