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Programmed death-ligand 1 expression and its correlation with clinicopathological parameters in gallbladder cancer

Journal of Pathology and Translational Medicine 2020년 54권 2호 p.154 ~ 164
김지혜, 김경빈, 김미성, 김영민, 서재희, 차희정, 최혜정,
소속 상세정보
김지혜 ( Kim Ji-Hye ) - Ulsan University Hospital Department of Pathology
김경빈 ( Kim Kyung-Bin ) - Ulsan University Hospital Department of Pathology
김미성 ( Kim Mi-Sung ) - Ulsan University Hospital Department of Pathology
김영민 ( Kim Young-Min ) - Ulsan University Hospital Department of Pathology
서재희 ( Suh Jae-Hee ) - Ulsan University Hospital Department of Pathology
차희정 ( Cha Hee-Jeong ) - Ulsan University Hospital Department of Pathology
최혜정 ( Choi Hye-Jeong ) - Ulsan University Hospital Department of Pathology

Abstract


Background: Immunomodulatory therapies targeting the interaction between programmed cell death protein 1 and programmed death-ligand 1 (PD-L1) have become increasingly important in anticancer treatment. Previous research on the subject of this immune response has established an association with tumor aggressiveness and a poor prognosis in certain cancers. Currently, scant information is available on the relationship between PD-L1 expression and gallbladder cancer (GBC).

Methods: We investigated the expression of PD-L1 in 101 primary GBC cases to determine the potential association with prognostic impact. PD-L1 expression was immunohistochemically assessed using a single PD-L1 antibody (clone SP263). Correlations with clinicopathological parameters, overall survival (OS), or progression- free survival (PFS) were analyzed.

Results: PD-L1 expression in tumor cells at cutoff levels of 1%, 10%, and 50% was present in 18.8%, 13.8%, and 7.9% of cases. Our study showed that positive PD-L1 expression at any cutoff was significantly correlated with poorly differentiated histologic grade and the presence of lymphovascular invasion (p < .05). PD-L1 expression at cutoff levels of 10% and 50% was significantly positive in patients with perineural invasion, higher T categories, and higher pathologic stages (p < .05). Additionally, there was a significant association noted between PD-L1 expression at a cutoff level of 50% and worse OS or PFS (p = .049 for OS, p = .028 for PFS). Other poor prognostic factors included histologic grade, T category, N category, pathologic stage, lymphovascular invasion, perineural invasion, growth pattern, and margin of resection (p < .05).

Conclusions: The expression of PD-L1 in GBC varies according to cutoff level but is valuably associated with poor prognostic parameters and survival. Our study indicates that the overexpression of PD-L1 in GBC had a negative prognostic impact.

키워드

Gallbladder neoplasm; Programmed death-ligand 1; Prognosis

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