잠시만 기다려 주세요. 로딩중입니다.

Primary carcinoid tumor in the external auditory canal

Journal of Pathology and Translational Medicine 2020년 54권 2호 p.184 ~ 187
정동해, 한규철, 김나래,
소속 상세정보
정동해 ( Chung Dong-Hae ) - Gachon University Gil Medical Center Department of Pathology
한규철 ( Han Gyu-Cheol ) - Gachon University Gil Medical Center Department of Otolaryngology
김나래 ( Kim Na-Rae ) - Gachon University Gil Medical Center Department of Pathology

Abstract


A 39-year-old man visited the department of otolaryngology due to an ongoing hearing disturbance that had lasted for 1 year. Temporal bone computed tomography revealed soft tissue density nearly obliterating the left external auditory canal (EAC). The mass was composed of sheets of round tumor cells containing moderate amounts of fine granular cytoplasm and salt and pepper chromatin. Neither mitosis nor necrosis was found. The Ki-67 proliferation index was less than 2%. Cells were positive for CD56 and synaptophysin but negative for chromogranin, cytokeratin (CK) 20, and CK7. Based on these findings, the tumor was diagnosed as a carcinoid tumor, well differentiated neuroendocrine carcinoma, grade 1 (G1) according to current World Health Organization (WHO) classification of head and neck tumors; and a neuroendocrine tumor, G1 according to neuroendocrine neoplasm (NEN)-2018 WHO standard classification. He remained free of local recurrence and metastasis after 20 months of follow up. To date, only six cases of primary NENs in the EAC have been reported. Metastatic tumor should be included in the differential diagnoses. Because of its rarity, the prognosis and treatment have not yet been clarified.

키워드

Carcinoid tumor; Neuroendocrine neoplasms; Carcinoma, neuroendocrine; External auditory canal

원문 및 링크아웃 정보

 

등재저널 정보