잠시만 기다려 주세요. 로딩중입니다.

Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease

Journal of Pathology and Translational Medicine 2020년 54권 3호 p.253 ~ 257
Koh Ji-Won, 전윤경,
소속 상세정보
 ( Koh Ji-Won ) - Seoul National University Hospital Department of Pathology
전윤경 ( Jeon Yoon-Kyung ) - Seoul National University Hospital Department of Pathology

Abstract


Follicular lymphoma (FL) with hyaline-vascular Castleman disease (FL-HVCD)-like features is a rare morphologic variant, with fewer than 20 cases in the literature. Herein, we report a case of FL-HVCD in a 37-year-old female who presented with isolated neck lymph node enlargement. The excised lymph node showed features reminiscent of HVCD, including regressed germinal centers (GCs) surrounded by onion skin-like mantle zones, lollipop lesions composed of hyalinized blood vessels penetrating into regressed GCs, and hyalinized interfollicular stroma. In addition, focal areas of abnormally conglomerated GCs composed of homogeneous, small centrocytes with strong BCL2, CD10, and BCL6 expression were observed, indicating partial involvement of the FL. Several other lymphoid follicles showed features of in situ follicular neoplasia. Based on the observations, a diagnosis of FL-HVCD was made. Although FLHVCD is very rare, the possibility of this variant should be considered in cases resembling CD. Identification of abnormal, neoplastic follicles and ancillary immunostaining are helpful for proper diagnosis.

키워드

Malignant lymphoma; Follicular lymphoma; Hyaline-vascular Castleman disease; In situ follicular neoplasia

원문 및 링크아웃 정보

 

등재저널 정보