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Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

Journal of Pathology and Translational Medicine 2020년 54권 3호 p.258 ~ 262
Ramakrishna Banumathi, Yewale Rohan, Vijayakumar Kavita, Radhakrishna Patta, Ramakrishna Balakrishnan Siddartha,
소속 상세정보
 ( Ramakrishna Banumathi ) - SRM Institutes for Medical Science Department of Pathology
 ( Yewale Rohan ) - SRM Institutes for Medical Science Department of Medical Gastroenterology
 ( Vijayakumar Kavita ) - SRM Institutes for Medical Science Department of Pathology
 ( Radhakrishna Patta ) - SRM Institutes for Medical Science Department of Surgical Gastroenterology
 ( Ramakrishna Balakrishnan Siddartha ) - SRM Institutes for Medical Science Department of Medical Gastroenterology

Abstract


IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our center. Two male patients aged 52 and 48 years presented with mass lesion in the stomach, which were clinically thought to be gastrointestinal stromal tumor, and they underwent excision of the lesion. Microscopic examination revealed marked fibrosis, which was storiform in one case, associated with diffuse lymphoplasmacytic infiltration and an increase in IgG4-positive plasma cells on immunohistochemistry. Serum IgG4 level was markedly elevated. Although rare, IgG4-related disease should be considered in the differential diagnosis of gastric submucosal mass lesions.

키워드

IgG4-related disease; Stomach; Autoimmune diseases; Gastrointestinal stromal tumors

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