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Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients

Journal of Pathology and Translational Medicine 2020년 54권 4호 p.265 ~ 275
김은규, 박소연, 김성원,
소속 상세정보
김은규 ( Kim Eun-Kyu ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Surgery
박소연 ( Park So-Yeon ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Pathology
김성원 ( Kim Sung-Won ) - Daerim St. Mary’s Hospital Department of Surgery

Abstract


BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients.

키워드

Breast neoplasms; Genes, BRCA1; Genes, BRCA2; Asian Continental Ancestry Group

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