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Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis

Journal of Pathology and Translational Medicine 2020년 54권 4호 p.300 ~ 309
정재한, 김내유, 표정수,
소속 상세정보
정재한 ( Jeong Jae-Han ) - Chosun University Hospital Department of Thoracic and Cardiovascular Surgery
김내유 ( Kim Nae-Yu ) - Eulji University Hospital Department of Internal Medicine
표정수 ( Pyo Jung-Soo ) - Eulji University Hospital Department of Pathology

Abstract


Background: In this meta-analysis, we aimed to evaluate the PAX8 immunohistochemical expressions in primary lung cancers and metastatic cancers to the lung.

Methods: We identified and reviewed relevant articles from the PubMed databases. Ultimately, 18 articles were included in this meta-analysis. PAX8 expression rates were analyzed and compared between primary and metastatic lung cancers.

Results: The PAX8 expression rate in primary lung cancers was 0.042 (95% confidence interval [CI], 0.025 to 0.071). PAX8 expression rates of small cell (0.129; 95% CI, 0.022 to 0.496) and non-small cell carcinomas of the lung (0.037; 95% CI, 0.022 to 0.061) were significantly different (p=.049 in a meta-regression test). However, the PAX8 expression rates of adenocarcinoma (0.013; 95% CI, 0.006 to 0.031) and squamous cell carcinoma (0.040; 95% CI, 0.016 to 0.097) were not significantly different. PAX8 expression rates of metastatic carcinomas to the lung varied, ranging from 1.8% to 94.9%. Metastatic carcinomas from the lung to other organs had a PAX8 expression rate of 6.3%. The PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid gland to the lung were higher than those of other metastatic carcinomas.

Conclusions: Primary lung cancers had a low PAX8 expression rate regardless of tumor subtype. However, the PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid were significantly higher than those of primary lung cancers.

키워드

PAX8; Immunohistochemistry; Lung; Primary; Metastatic; Meta-analysis

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