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Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Journal of Pathology and Translational Medicine 2020년 54권 4호 p.340 ~ 345
최소연, 김지혜, 김경빈, 김미성, 최혜정, 김영민, 서재희, 서민정, 차희정,
소속 상세정보
최소연 ( Choi So-Yeon ) - Ulsan University Hospital Department of Pathology
김지혜 ( Kim Ji-Hye ) - Ulsan University Hospital Department of Pathology
김경빈 ( Kim Kyung-Bin ) - Ulsan University Hospital Department of Pathology
김미성 ( Kim Mi-Sung ) - Ulsan University Hospital Department of Pathology
최혜정 ( Choi Hye-Jeong ) - Ulsan University Hospital Department of Pathology
김영민 ( Kim Young-Min ) - Ulsan University Hospital Department of Pathology
서재희 ( Suh Jae-Hee ) - Ulsan University Hospital Department of Pathology
서민정 ( Seo Min-Jung ) - Ulsan University Hospital Department of Nuclear Medicine
차희정 ( Cha Hee-Jeong ) - Ulsan University Hospital Department of Pathology

Abstract


Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), is one of the specific type of low-grade B-cell lymphoma not infrequently found worldwide. It typically involves mucosal sites such as stomach and conjunctiva; however, primary hepatic MALT lymphoma has been extremely rarely reported. We describe a case of hepatic MALT lymphoma in a 70-year-old male patient who underwent left hepatectomy due to the incidentally detected liver masses at a medical checkup. The resected specimen revealed multinodular masses consisting of small-to-intermediate-sized lymphoid cells with serpentine pattern and focal lymphoepithelial lesions. The tumor cells were diffusely positive for CD20 and Bcl-2 but negative for CD3, CD10, CD5, CD23, CD43, and cyclinD1. The Ki-67 labeling index was 10% and immunoglobulin heavy chain gene rearrangement study confirmed monoclonal proliferation. In this paper, we discuss several unique clinicopathologic characteristics which will be helpful to the differential diagnosis of hepatic MALT lymphoma.

키워드

Lymphoma, B-cell, marginal zone; Mucosa-associated lymphoid tissue; Liver

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