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비만한 한국 소아청소년에서 흑색가시세포증 정도에 따른 인슐린 저항성과 비만 정도

Insulin Resistance and Obesity according to Degree of Acanthosis Nigricans in Obese Korean Children and Adolescents

가정의학 2020년 10권 5호 p.332 ~ 337
Lee Byung-Gue, 박경희, 서영균, 노혜미, 송홍지, 백유진, Park Mi-Jeong, Jo Ah-Ra,
소속 상세정보
 ( Lee Byung-Gue ) - Hallym University Sacred Heart Hospital Department of Family Medicine
박경희 ( Park Kyung-Hee ) - Hallym University Sacred Heart Hospital Department of Family Medicine
서영균 ( Seo Young-Gyun ) - Hallym University Sacred Heart Hospital Department of Family Medicine
노혜미 ( Noh Hye-Mi ) - Hallym University Sacred Heart Hospital Department of Family Medicine
송홍지 ( Song Hong-Ji ) - Hallym University Sacred Heart Hospital Department of Family Medicine
백유진 ( Paek Yu-Jin ) - Hallym University Sacred Heart Hospital Department of Family Medicine
 ( Park Mi-Jeong ) - Hallym University Sacred Heart Hospital Department of Family Medicine
 ( Jo Ah-Ra ) - Hallym University Sacred Heart Hospital Department of Family Medicine

Abstract


Background: Recent studies suggest that acanthosis nigricans (AN) is associated with insulin resistance in obese children. However, very few studies have assessed insulin resistance and obesity according to the degree of AN. Therefore, this study aimed to investigate the correlation between the degree of obesity and insulin resistance according to the severity of AN.

Methods: A total of 141 participants (83 boys and 58 girls) aged 6?17 years were recruited for the Intervention for Childhood and Adolescents obesity via Activity and Nutrition study between 2016 and 2017. The participants were categorized into four groups according to the severity of AN: grade 0 (n=69), grade 1 (n=19), grade 2?3 (n=35), and grade 4 (n=18). All participants underwent physical examination and blood tests. We compared the mean homeostatic model assessment (HOMA-IR) and body mass index Z score (BMI Z-score) in each group using ANCOVA and linear regression model.

Results: The HOMA-IR, which represents insulin resistance, increased with increasing AN severity (grade 0 group: 3.25±0.070; grade 1 group: 3.97±0.103; grade 2?3 group: 4.76±0.079; AN grade 4: 6.40±0.107; P for trend<0.001). Similarly, the BMI Z-score, which represents the degree of obesity, increased with increasing AN severity (grade 0 group: 2.29±0.052; grade 1 group: 2.42±0.080; grade 2?3 group: 2.44±0.062, grade 4: 2.67±0.089; P for trend<0.001).

Conclusion: Insulin resistance and the degree of obesity increase with the severity of AN in Korean obese children.

키워드

Acanthosis Nigricans; Adolescents; Insulin Resistance; Body Mass Index

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