잠시만 기다려 주세요. 로딩중입니다.

폐경 여성에서 혈청 저밀도지단백 콜레스테롤 농도의 예측 인자

Predictors of Serum Low-Density Lipoprotein Cholesterol Level in Postmenopausal Women

가정의학 2020년 10권 5호 p.393 ~ 397
정동, 최희정, 심예나, 조민소, 오한진,
소속 상세정보
정동 ( Jung Dong ) - Eulji University Hospital Department of Family Medicine
최희정 ( Choi Hee-Jeong ) - Eulji University Hospital Department of Family Medicine
심예나 ( Shim Ye-Na ) - Eulji University Hospital Department of Family Medicine
조민소 ( Jo Min-So ) - Eulji University Hospital Department of Family Medicine
오한진 ( Oh Han-Jin ) - Eulji University Hospital Department of Family Medicine

Abstract


Background: In general, women tend to increase serum low-density lipoprotein cholesterol levels after menopause. Hypercholesterolemia is a risk factor that causes atherosclerosis and increases the risk of cardiovascular disease. Additionally, low-density lipoprotein cholesterol increases even when attempting to modify lifestyles in menopausal women. Therefore, we wanted to find out what risk factors are associated with low-density lipoprotein cholesterol in menopausal women.

Methods: Data were gathered from 4,943 subjects who had visited a Health Promotion Center. Variables are measured in body metering and blood tests. Partial correlation analysis was performed to identify the variables that are related to low-density lipoprotein cholesterol, and multiple regression analysis was performed to find the variables that can predict low-density lipoprotein cholesterol.

Results: The mean age of the subjects was 57.3±6.6 years old, the average low density lipoprotein cholesterol concentration was 124.6±33.3 mg/dL, the average body mass index was 23.6±3.2 kg/m2, and the average waist circumference was 78.4±8.3 cm, and 21.5 percent of subjects was abdominal obesity. Serum low-density lipoprotein cholesterol level showed a positive correlation with obesity, oxidative stress-related indices, and inflammatory markers such as ESR, CRP. ESR, body fat mass, total bilirubin, uric acid, fasting plasma glucose, and WBC count showed positive correlation with serum low-density lipoprotein cholesterol levels, and age showed negative correlation.

Conclusion: This study identified several factors, such as inflammatory markers, obesity and oxidative stress related indices were associated with elevated serum low-density lipoprotein cholesterol levels in postmenopausal women.

키워드

Menopause; Cholesterol, LDL; Dyslipidemias; Risk Factors

원문 및 링크아웃 정보

등재저널 정보