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Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH

Clinical and Molecular Hepatology 2020년 26권 4호 p.383 ~ 400
Hydes Theresa J., Ravi Sujan, Loomba Rohit, Gray Meagan E.,
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 ( Hydes Theresa J. ) - University of Alabama at Birmingham Division of Gastroenterology and Hepatology
 ( Ravi Sujan ) - University of Alabama at Birmingham Division of Gastroenterology and Hepatology
 ( Loomba Rohit ) - University of California Division of Gastroenterology
 ( Gray Meagan E. ) - University of Alabama at Birmingham Division of Gastroenterology and Hepatology

Abstract


Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and affects approximately one third of adults in the United States. The disease is becoming a global epidemic as a result of the rising rates of obesity and metabolic disease. Emerging data suggest weight loss of ≥10% overall body weight is beneficial in resolving steatosis and reversing fibrosis. Prospective trials comparing various diets are limited by lack of sufficient power as well as pre- and post-treatment histopathology, and therefore no specific diet is recommended at this time. In this narrative review we examine the pathophysiology behind specific macronutrient components that can either promote or reverse NAFLD to help inform more specific dietary recommendations. Overall, the data supports reducing saturated fat, refined carbohydrates, and red and processed meats in the diet, and increasing the consumption of plant-based foods. Diets that incorporate these recommendations include plant-based diets such as the Dietary Approaches to Stop Hypertension, Mediterranean, vegetarian, and vegan diets.

키워드

Diet, Vegetarian; Diet, Healthy; Nonalcoholic fatty liver disease; Diet

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