잠시만 기다려 주세요. 로딩중입니다.

Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea

Clinical and Molecular Hepatology 2020년 26권 4호 p.562 ~ 576
이유림, 강민규, 송정은, 김현정, 권영오, 탁원영, 장세영, 박정길, 이창형, 황재석, 장병국, 서정일, 정우진, 김병석, 박수영,
소속 상세정보
이유림 ( Lee Yu-Rim ) - Kyungpook National University School of Medicine Department of Internal Medicine
강민규 ( Kang Min-Kyu ) - Yeungnam University College of Medicine Department of Internal Medicine
송정은 ( Song Jeong-Eun ) - Daegu Catholic University School of Medicine Department of Internal Medicine
김현정 ( Kim Hyun-Jung ) - Keimyung University School of Medicine Department of Internal Medicine
권영오 ( Kweon Young-Oh ) - Kyungpook National University School of Medicine Department of Internal Medicine
탁원영 ( Tak Won-Young ) - Kyungpook National University School of Medicine Department of Internal Medicine
장세영 ( Jang Se-Young ) - Kyungpook National University School of Medicine Department of Internal Medicine
박정길 ( Park Jung-Gil ) - Yeungnam University College of Medicine Department of Internal Medicine
이창형 ( Lee Chang-Hyeong ) - Daegu Catholic University School of Medicine Department of Internal Medicine
황재석 ( Hwang Jae-Seok ) - Keimyung University School of Medicine Department of Internal Medicine
장병국 ( Jang Byoung-Kuk ) - Keimyung University School of Medicine Department of Internal Medicine
서정일 ( Suh Jeong-Ill ) - Dongguk University College of Medicine Dongguk University Gyeongju Hospital Department of Internal Medicine
정우진 ( Chung Woo-Jin ) - Keimyung University School of Medicine Department of Internal Medicine
김병석 ( Kim Byung-Seok ) - Daegu Catholic University School of Medicine Department of Internal Medicine
박수영 ( Park Soo-Young ) - Kyungpook National University School of Medicine Department of Internal Medicine

Abstract


Background/Aims: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved.

Methods: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed.

Results: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20?17.02;P=0.026) and death (hazard ratio, 2.86; 95% CI, 1.04?9.30; P=0.042) in COVID-19 patients.

Conclusions: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients.

키워드

Liver diseases; Liver cirrhosis; Prognosis; Mortality; COVID-19

원문 및 링크아웃 정보

등재저널 정보