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Roles of the complement system in alcohol-induced liver disease

Clinical and Molecular Hepatology 2020년 26권 4호 p.677 ~ 685
Zhou Yi, Yuan Guandou, Zhong Fudi, He Songqing,
소속 상세정보
 ( Zhou Yi ) - Guangxi Medical University First Affiliated Hospital Division of Hepatobiliary Surgery
 ( Yuan Guandou ) - Guangxi Medical University First Affiliated Hospital Division of Hepatobiliary Surgery
 ( Zhong Fudi ) - Guangxi Medical University First Affiliated Hospital Division of Hepatobiliary Surgery
 ( He Songqing ) - Guangxi Medical University First Affiliated Hospital Division of Hepatobiliary Surgery

Abstract


Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.

키워드

Complement system proteins; Liver Diseases; Alcoholic; Molecular targeted therapy

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