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Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015?2017)

Nam Do-Jin, 김예지, Yang Eun-Hye, 이효춘, 유재홍,
소속 상세정보
 ( Nam Do-Jin ) - Kyung Hee University Hospital Department of Occupational and Environmental Medicine
김예지 ( Kim Ye-Ji ) - Kyung Hee University Hospital Department of Occupational and Environmental Medicine
 ( Yang Eun-Hye ) - Kyung Hee University Hospital Department of Occupational and Environmental Medicine
이효춘 ( Lee Hyo-Choon ) - Kyung Hee University Hospital Department of Occupational and Environmental Medicine
유재홍 ( Ryoo Jae-Hong ) - Kyung Hee University Hospital Department of Occupational and Environmental Medicine

Abstract


Background: We aimed to determine relationship diabetes according to urinary phthalate metabolites using adult data from Korean National Environmental Health Survey cycle 3 (2015?2017).

Method: This study was conducted on 3,781 adults aged 19 years and older (1,648 men and 2,133 women) based on KoNEHS cycle 3. Participants' data were analyzed by gender; Relationship between phthalate metabolites in the urine and diabetes was analyzed by dividing the sociodemographic variables, health behavior-related variables, and urinary phthalate metabolite concentrations into quartiles. To determine the relationship between urinary phthalate metabolites and the prevalence of diabetes, the odds ratio (OR) was calculated using logistic regression analysis.

Results: Based on the 1st quartile of each metabolite, the ORs for di-2-ethylhexyl phthalate (DEHP) (4th quartile), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2nd quartile, 3rd quartile and 4th quartile), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (4th quartile), mono-(2-ethyl-5-carboxypentyl) phthalate (MECCP) (4th quartile), mono-n-butyl phthalate (MnBP) (3rd quartile and 4th quartile), mono-benzyl phthalate (MBzP) (2nd quartile) and 4th quartile), and mono (3-carboxypropyl) phthalate (MCPP) (3rd quartile and 4th quartile) were significantly higher after the adjustment in men. The ORs for DEHP (2nd quartile, 3rd quartile and 4th quartile), MEHHP (2nd quartile, 3rd quartile and 4th quartile), MEOHP (4th quartile), MECCP (4th quartile), MBzP (4th quartile), and MCPP (4th quartile) were significantly higher after the adjustment in women.

Conclusion: This study investigated relationship between urinary phthalate metabolites and diabetes. The higher urinary phthalate metabolites, the higher the prevalence of diabetes. Further regulation of phthalate may be needed, and further studies are warranted to confirm the association between phthalate concentration and other chronic diseases (such as hypertension, hyperlipidemia, and cardiovascular disease).

키워드

Mono-(2-ethyl-5-oxohexyl) phthalate; Monobutyl phthalate; Diabetes mellitus; Korea; Environmental monitoring

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