Overlap syndrome of Miller-Fisher syndrome/Pharyngeal-Cervical-Brachial variant-Guillain Barre Syndrome with anti-ganglioside complex antibodies
이석윤, 오성일, 허소영, 신경진, 김종국, 윤별아,
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이석윤 ( Lee Suk-Yoon ) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Neurology
오성일 ( Oh Seong-Il ) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Neurology
허소영 ( Huh So-Young ) - Kosin University College of Medicine Department of Neurology
신경진 ( Shin Kyong-Jin ) - Inje University Haeundae Paik Hospital Department of Neurology
김종국 ( Kim Jong-Kuk ) - Dong-A University College of Medicine Peripheral Neuropathy Research Center
윤별아 ( Yoon Byeol-A ) - Dong-A University College of Medicine Peripheral Neuropathy Research Center
Abstract
Guillain-Barre syndrome (GBS) and Miller Fisher syndrome (MFS) can present with overlapping features. A 56-year-old female developed ptosis and diplopia after an upper respiratory infection, and presented with facial palsy, dysarthria, brachial weakness, ataxia, and areflexia. Mild weakness of both legs appeared after a few days. Anti-ganglioside complex antibody were positive to IgG GM1/GQ1b and GQ1b/sulfatide antibodies. The present case suggests that the manifestation of overlap between MFS/PCB variants and GBS could be caused by antiganglioside complex antibodies.
키워드
Guillain-Barre syndrome; Miller Fisher syndrome; Pharyngeal-cervical-brachial variant; Antibodies; Ganglioside; Anti-ganglioside complex
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