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Current Diagnosis and Management of Hypersensitivity Pneumonitis

Tuberculosis and Respiratory Diseases 2020년 83권 2호 p.122 ~ 131
Leone Paolo Maria, Richeldi Luca,
소속 상세정보
 ( Leone Paolo Maria ) - Fondazione Policlinico Universitario A. Gemelli IRCCS
 ( Richeldi Luca ) - Fondazione Policlinico Universitario A. Gemelli IRCCS

Abstract


Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial inflammation and architectural distortion. The underlying pathogenetic mechanisms are unclear. The absence of international shared diagnostic guidelines and the lack of a “gold-standard” test for HP combined with the presence of several clinical and radiologic overlapping features makes it particularly challenging to differentiate HP from other ILDs, also in expert contests. Radiology is playing a more crucial role in this process; recently the headcheese sign was recognized as a more specific for chronic-HP than the extensive mosaic attenuation. Several classification proposals and diagnostic models have been advanced by different groups, with no prospective validation. Therapeutic options for HP have been limited to antigen avoidance and immunosuppressant drugs over the last decades. Several questions about this condition remain unanswered and there is a need for more studies.

키워드

Hypersensitivity Pneumonitis; Lung Diseases, Interstitial; Fibrosis; Diagnosis; Management; High Resolution Computed Tomography; Therapy; Steroids; Antigens; Nintedanib; Pirfenidone

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