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Risk Factor and Mortality in Patients with Pulmonary Embolism Combined with Infectious Disease

Tuberculosis and Respiratory Diseases 2020년 83권 2호 p.157 ~ 166
이기동, 주선미, 김주영, 김태훈, 유정완, 이승준, 조유지, 정이영, 전경녀, 이종덕, 김호철,
소속 상세정보
이기동 ( Lee Gi-Dong ) - Saint Carollo Hospital Department of Internal Medicine
주선미 ( Ju Sun-Mi ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
김주영 ( Kim Ju-Young ) - Gyeongsang National University School of Medicine Gyeongsang National University Changwon Hospital Department of Internal Medicine
김태훈 ( Kim Tae-Hoon ) - Gyeongsang National University School of Medicine Gyeongsang National University Changwon Hospital Department of Internal Medicine
유정완 ( Yoo Jung-Wan ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
이승준 ( Lee Seung-Jun ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
조유지 ( Cho Yu-Ji ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
정이영 ( Jeong Yi-Yeong ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
전경녀 ( Jeon Kyung-Nyeo ) - Gyeongsang National University School of Medicine Gyeongsang National University Changwon Hospital Department of Radiology
이종덕 ( Lee Jong-Deog ) - Gyeongsang National University School of Medicine Gyeongsang National University Hospital Department of Internal Medicine
김호철 ( Kim Ho-Cheol ) - Gyeongsang National University School of Medicine Gyeongsang National University Changwon Hospital Department of Internal Medicine

Abstract


Background: Infectious conditions may increase the risk of venous thromboembolism. The purpose of this study was to evaluate the risk factor for combined infectious disease and its influence on mortality in patients with pulmonary embolism (PE).

Methods: Patients with PE diagnosed based on spiral computed tomography findings of the chest were retrospectively analyzed. They were classified into two groups: patients who developed PE in the setting of infectious disease or those with PE without infection based on review of their medical charts.

Results: Of 258 patients with PE, 67 (25.9%) were considered as having PE combined with infectious disease. The sites of infections were the respiratory tract in 52 patients (77.6%), genitourinary tract in three patients (4.5%), and hepatobiliary tract in three patients (4.5%). Underlying lung disease (odds ratio [OR], 3.69; 95% confidence interval [CI], 1.926?7.081; p<0.001), bed-ridden state (OR, 2.84; 95% CI, 1.390?5.811; p=0.004), and malignant disease (OR, 1.867; 95% CI, 1.017?3.425; p=0.044) were associated with combined infectious disease in patients with PE. In-hospital mortality was higher in patients with PE combined with infectious disease than in those with PE without infection (24.6% vs. 11.0%, p=0.006). In the multivariate analysis, combined infectious disease (OR, 4.189; 95% CI, 1.692?10.372; p=0.002) were associated with non-survivors in patients with PE.

Conclusion: A substantial portion of patients with PE has concomitant infectious disease and it may contribute a mortality in patients with PE.

키워드

Pulmonary Embolism; Infectious Disease; Mortality

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