잠시만 기다려 주세요. 로딩중입니다.

Vesicles Comprising Dimethylaminopropyl Octadecanamide, Stearic Acid, and Carboxyhexadecyl Disulfide and Their Release Property under Reducing Condition

Biotechnology and Bioprocess Engineering 2020년 25권 5호 p.690 ~ 698
김진아, 김진철,
소속 상세정보
김진아 ( Kim Jin-Ah ) - Kangwon National University College of Biomedical Sciences Department of Medical Biomaterials Engineering
김진철 ( Kim Jin-Chul ) - Kangwon National University College of Biomedical Sciences Department of Medical Biomaterials Engineering

Abstract


Vesicles comprising dimethyl aminopropyl octadecanamide (DMAPODA), stearic acid (SA), and carboxyhexadecyl disulfide (CHDDS) were prepared as reduction-responsive carriers. Vesicular particles were found on TEM micrographs and the diameter fell within 100-400 nm. The hydrodynamic mean diameter increased with increasing the content of CHDDS. The zeta potential was lowered by the incorporation of CHDDS into the vesicular membrane. Vesicle whose DMAPODA/SA/ CHDDS molar ratio was 1/1/5 exhibited one endothermic peak around 50.9°C, indicating that the vesicular membrane was homogeneous in the composition. Strong signals were found in 500-540 cm-1 in the Raman spectrum of vesicles, suggesting that the disulfide lipid (i.e. CHDDS) was incorporated into the vesicular membranes. Vesicles containing CHDDS released rhodamine B in dithiothreitol (DTT, a reducing agent) concentration-dependent manner. The DTTsensitivity of the vesicles in terms of release was higher as the CHDDS content was higher.

키워드

dimethyl aminopropyl octadecanamide; carboxyhexadecyl disulfide; vesicular carrier; reduction-induced release; rhodamine B

원문 및 링크아웃 정보

등재저널 정보