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Biological treatments for severe asthma

Yeungnam University Journal of Medicine 2020년 37권 4호 p.262 ~ 268
진현정,
소속 상세정보
진현정 ( Jin Hyun-Jung ) - Yeungnam University College of Medicine Department of Internal Medicine

Abstract


Severe asthma patients comprise about 3% to 13% of all asthma patients, but they have higher hospital utilization rates and higher medical costs than those of nonsevere asthma patients. Treatment methods for severe asthma patients are still lacking; however, the recent development of biologics is expected to have a positive effect. The biological therapies developed so far are mainly aimed at treating asthma patients with type 2 inflammation. These biologics have been found to reduce symptoms of asthma, improve lung function, reduce the use of oral corticosteroids, and improve quality of life of patients. This article reviews the mechanism of action and indications for approved biologics and discusses what should be considered when choosing biologics.

키워드

Biological products; Eosinophils; Monoclonal antibodies; Severe asthma

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