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Effects of exercise training on the biochemical pathways associated with sarcopenia

Journal of Exercise Nutrition & Biochemistry 2020년 24권 3호 p.32 ~ 38
Seo Dae-Yun, 황부근,
소속 상세정보
 ( Seo Dae-Yun ) - Inje University Cardiovascular and Metabolic Disease Center
황부근 ( Hwang Boo-Geun ) - Tongmyong University Department of Sport Rehabilitation

Abstract


Purpose: Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated.

Methods: We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia.

Results: This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia.

Conclusion: This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.

키워드

aerobic exercise; resistance exercise; sarcopenia; aging; skeletal muscle; IGF-1; PI3K; AKT; mTOR; TNF-α; Atrogin; MuRF1/2; ROS

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