잠시만 기다려 주세요. 로딩중입니다.

Response of the oxygen uptake efficiency slope to exercise training in patients with chronic kidney disease

Kidney Research and Clinical Practice 2020년 39권 3호 p.305 ~ 317
이주영, Watson Emma L., Vadaszy Noemi, Baker Luke A., Viana Joao L., Smith Alice C.,
소속 상세정보
이주영 ( Wilkinson Thomas J. ) - University of Leicester Department of Health Sciences
 ( Watson Emma L. ) - University of Leicester Department of Cardiovascular Sciences
 ( Vadaszy Noemi ) - University of Leicester Department of Health Sciences
 ( Baker Luke A. ) - University of Leicester Department of Health Sciences
 ( Viana Joao L. ) - University Institute of Maia CIDESD Research Center in Sports Sciences, Health Sciences and Human Development
 ( Smith Alice C. ) - University of Leicester Department of Health Sciences

Abstract


Background: Chronic kidney disease (CKD) patients have poor cardiorespiratory fitness. Although cardiopulmonary exercise testing (CPET) is a universal assessment of cardiorespiratory fitness, values taken at ‘peak’ effort are strongly influenced by motivation and the choice of test endpoint. The oxygen uptake efficiency slope (OUES) integrates cardiovascular, musculoskeletal, and respiratory function into a single index to provide a more pragmatic and safer alternative to maximal testing. No research has explored whether exercise can improve the OUES in CKD patients.

Methods: Thirty-two patients with non-dialysis CKD were recruited into a 12-week exercise program consisting of mixed aerobic and resistance training three times a week. CPET was conducted at baseline, and then, following a 6-week control period, at pre- and post-exercise intervention. Direct measurements of oxygen consumption (V?O2) and ventilatory parameters were collected. The OUES was calculated as the relationship between V?O2 and the log10 of minute ventilation (V?E).

Results: No changes were observed in any variable during the control period, although modest increases in V?O2peak were observed. No meaningful changes were observed as a result of exercise in any cardiorespiratory value obtained. The OUES calculated at 100%, 90%, 75%, and 50% of exercise duration did not change significantly after 12 weeks of exercise training.

Conclusion: Our results show that 12 weeks of exercise training had no beneficial effects on the OUES, which supports the modest change observed in V?O2peak. The lack of change in the OUES and other parameters could indicate a dysfunctional cardiorespiratory response to exercise in patients with CKD, likely mediated by dysfunctional peripheral metabolic mechanisms.

키워드

Chronic kidney disease; Exercise test; Exercise therapy; Oxygen consumption; Physical fitness

원문 및 링크아웃 정보

등재저널 정보