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Hair Cortisol as a Marker of Intergenerational Heritage of War? A Study of Veterans and Their Offspring

Psychiatry Investigation 2020년 17권 10호 p.976 ~ 986
Castro-Vale Ivone, van Rossum Elisabeth F. C., Staufenbiel Sabine M., Severo Milton, Mota-Cardoso Rui, Carvalho Davide,
소속 상세정보
 ( Castro-Vale Ivone ) - University of Porto Faculty of Medicine Department of Clinical Neurosciences and Mental Health
 ( van Rossum Elisabeth F. C. ) - Erasmus MC University Medical Center Rotterdam Department of Internal Medicine
 ( Staufenbiel Sabine M. ) - Erasmus MC University Medical Center Rotterdam Department of Internal Medicine
 ( Severo Milton ) - University of Porto Faculty of Medicine Department of Clinical Epidemiology, Predictive Medicine and Public Health
 ( Mota-Cardoso Rui ) - University of Porto Faculty of Medicine Department of Clinical Neurosciences and Mental Health
 ( Carvalho Davide ) - Universidade do Porto i3S-Instituto de Investigacao e Inovacao em Saude

Abstract


Objective: Posttraumatic stress disorder (PTSD) has been associated with lower circulating cortisol levels in specific subgroups, which have also been found in the offspring of people with PTSD. The analysis of hair cortisol concentrations (HCC) is a recent methodology which is used to assess long-term systemic cortisol levels. We aimed to study veterans with war-related lifetime PTSD and their respective offspring with regards to HCC. We also studied the influence of lifetime major depressive disorder (MDD), war experiences, and childhood adversities on HCC in these groups.

Methods: 31 male veterans with PTSD and 28 without PTSD and 69 adult offspring were studied. HCC were quantified by liquid chromatography tandem-mass spectrometry.

Results: No differences in HCC were found between veterans with and without PTSD, or between their respective offspring. Veterans without MDD showed a positive association between total war exposure and HCC. Veterans reporting more frequent childhood physical abuse had lower HCC. Veterans-with-PTSD’s offspring with MDD had increased HCC compared to offspring without MDD. Offspring’s exposure to more frequent childhood physical abuse was negatively associated with HCC in those without MDD.

Conclusion: HCC did not appear to constitute a marker of intergenerational heritage of war-related PTSD, except in the case of veteranswith-PTSD’s offspring with MDD. Our data suggest that HCC is a marker of adult reported childhood physical abuse.

키워드

Posttraumatic stress disorder; Hair cortisol; War veterans; Intergenerational transmission; Major depressive disorder; Childhood adversities

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