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The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder

Psychiatry Investigation 2020년 17권 10호 p.996 ~ 1005
김은지, 권영준, 이화영, 윤희정, 김지선, 심세훈,
소속 상세정보
김은지 ( Kim Eun-Jee ) - Soonchunhyang University College of Medicine Cheonan Hospital Department of Psychiatry
권영준 ( Kwon Young-Joon ) - Soonchunhyang University College of Medicine Cheonan Hospital Department of Psychiatry
이화영 ( Lee Hwa-Young ) - Soonchunhyang University College of Medicine Cheonan Hospital Department of Psychiatry
윤희정 ( Yoon Hee-Jung ) - Korean Society of Infectious Diseases
김지선 ( Kim Ji-Sun ) - Soonchunhyang University College of Medicine Cheonan Hospital Department of Psychiatry
심세훈 ( Shim Se-Hoon ) - Soonchunhyang University College of Medicine Cheonan Hospital Department of Psychiatry

Abstract


Objective: Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.

Methods: A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19?45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.

Results: MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.

Conclusion: The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

키워드

Event related potential; GoNogo; Adult; ADHD; Depression

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