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Association of Alcohol Intake and Fracture Risk in Elderly Varied by Affected Bones: A Nationwide Longitudinal Study

Psychiatry Investigation 2020년 17권 10호 p.1013 ~ 1020
왕성민, 한경도, 김낙영, 엄유현, 강동우, 나해란, 이창욱, 임현국,
소속 상세정보
왕성민 ( Wang Sheng-Min ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Psychiatry
한경도 ( Han Kyung-Do ) - Soongsil University Department of Statistics and Actuarial Science
김낙영 ( Kim Nak-Young ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Psychiatry
엄유현 ( Um Yoo-Hyun ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Psychiatry
강동우 ( Kang Dong-Woo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Psychiatry
나해란 ( Na Hae-Ran ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Psychiatry
이창욱 ( Lee Chang-Uk ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Psychiatry
임현국 ( Lim Hyun-Kook ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Psychiatry

Abstract


Objective: Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly subjects and further analyzed whether the association varied by fracture locations.

Methods: This is a nationwide population-based cohort study which included all people aged 66 (n=1,431,539) receiving the National Screening Program during 2009?2014. Time-to-event were defined as duration from study recruitment, the day they received health screening, to the occurrence of fracture.

Results: Total fracture was significantly lower in mild drinkers [adjusted hazard ratio (aHR)=0.952; 95% confidence interval (95% CI) =0.931?0.973] and higher in heavy drinkers (aHR=1.246; 95% CI=1.201?1.294) than non-drinkers. Risk pattern of alcohol consumption and fracture differed according to affected bones. Similar J-shaped trends were observed for vertebra fractures, but risk of limb fracture showed a linear relationship with alcohol intake. For hip fracture, risk decrement was more pronounced in mild and moderate drinkers, and significant increment was noted only in very severe drinkers [≥60 g/day; (aHR)=1.446; 1.162?1.801].

Conclusion: Light to moderate drinking generally lowered risk of fractures, but association between alcohol and fracture risk varied depending on the affected bone lesions.

키워드

Geriatric psychiatry; Addictive disorder; Community psychiatry; Epidemiology

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