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Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia

Psychiatry Investigation 2020년 17권 10호 p.1031 ~ 1036
최광연, Choo Jeong-Min, 이윤정, 이유진, 조철현, 김승현,
소속 상세정보
최광연 ( Choi Kwang-Yeon ) - Chungnam National University College of Medicine Department of Psychiatry
 ( Choo Jeong-Min ) - Korea University College of Medicine Department of Surgery
이윤정 ( Lee Youn-Jung ) - Gyeongsang National University School of Medicine Department of Psychiatry
이유진 ( Lee Yu-Jin ) - Seoul Metropolitan Eunpyeong Hospital Department of Psychiatry
조철현 ( Cho Chul-Hyun ) - Chungnam National University College of Medicine Department of Psychiatry
김승현 ( Kim Seung-Hyun ) - Korea University College of Medicine Department of Psychiatry

Abstract


Objective: Interleukin-10 (IL-10) is a major immunoregulatory cytokine and its gene plays a fundamental role in anti-inflammatory and immunosuppressive activity. This study aimed to examine the association between the IL10 gene promoter -1082G/A polymorphism (rs1800896) and tardive dyskinesia (TD) in schizophrenia.

Methods: Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). TD was diagnosed using the Research Diagnostic Criteria for TD and Abnormal Involuntary Movement Scale (AIMS). Genotyping was performed by RT-PCR and high-resolution melting curve analysis.

Results: The distributions of genotypic frequencies did not differ between patients with and without TD (χ2=4.33, p=0.115). However, allelic frequencies of the two groups were different (χ2=4.45, p=0.035); the A allele frequency was higher in TD. The total AIMS scores of the three genotypes were not different (F=1.33, p=0.266). However, the total AIMS scores of the A allele carrier and the A allele non-carrier were significantly different (t=5.79, p<0.001). Logistic regression analaysis showed that IL10 -1082G/A genotype significantly predicts presence of TD (p=0.045) after adjusting for covariates such as age and treatment duration.

Conclusion: This finding suggests that the A allele of rs1800896 may be associated with TD development following a low IL-10 function.

키워드

Tardive dyskinesia; Oxidative stress; Interleukin-10

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