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인디언구스베리와 님잎 추출물을 함유한 복합 처방의 항산화 및 숙취해소 효과

Antioxidant and Hangover Cure Effects of Compound Prescription Containing Phyllanthus emblica and Azadirachta Indica Leaf Extract

동의생리병리학회지 2020년 34권 5호 p.229 ~ 237
이수빈, 주인환, 박종민, 한수현, 위영준, 김동희,
소속 상세정보
이수빈 ( Lee Su-Bin ) - Daejeon University College of Korean Medicine Department of Pathology
주인환 ( Joo In-Hwan ) - Daejeon University College of Korean Medicine Department of Pathology
박종민 ( Park Jong-Min ) - Daejeon University College of Korean Medicine Department of Pathology
한수현 ( Han Su-Hyun ) - Daejeon University College of Korean Medicine Department of Pathology
위영준 ( Wi Young-Joon ) - Hanul
김동희 ( Kim Dong-Hee ) - Daejeon University College of Korean Medicine Department of Pathology

Abstract


The purpose of this study was to investigate the antioxidant and hangover cure effects of compound prescription containing Phyllanthus emblica and Azadirachta Indica leaf extract (CP). In vitro experiments, HepG2 cells were induced oxidative stress by hydrogen peroxide (H2O2) and treated with CP at 50, 100, 200 ㎍/㎖ concentration. Antioxidant enzyme (superoxide dismutase (SOD), catalse (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity and glutathione (GSH) content were decreased by hydrogen peroxide-induced oxidative stress, but CP was increased that. In vivo experiments, experiment rats were orally administered alcohol 3 g/kg and, after 30 min administered CP 200 ㎎/㎏. After 1 and 3 h of alcohol administration, blood was collected from the tail vein, while after 5 h, blood was collected from the heart. CP modulates alcohol dehydrogenase (ADH) and acetaldehyde level, thereby decreased alcohol level in serum. Also, CP decreased the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These results suggest that CP has antioxidant effects and alleviates alcohol hangover symptoms.

키워드

Alcohol; Antioxidant; Azadirachta Indical; Pyllanthus emblicand; Hangover

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