잠시만 기다려 주세요. 로딩중입니다.

Understanding Muscle Protein Dynamics: Technical Considerations for Advancing Sarcopenia Research

Annals of Geriatric Medicine and Research 2020년 24권 3호 p.157 ~ 165
김일영, 박상희, 장지웅, Wolfe Robert R.,
소속 상세정보
김일영 ( Kim Il-Young ) - Gachon University College of Medicine Department of Molecular Medicine
박상희 ( Park Sang-Hee ) - Gachon University Lee Gil Ya Cancer and Diabetes Institute Korea Mouse Metabolic Phenotyping Center (KMMPC)
장지웅 ( Jang Ji-Woong ) - Gachon University Lee Gil Ya Cancer and Diabetes Institute Korea Mouse Metabolic Phenotyping Center (KMMPC)
 ( Wolfe Robert R. ) - University of Arkansas for Medical Sciences Department of Geriatrics

Abstract


Sarcopenia, which is the loss of muscle mass and strength that occurs with aging, involves imbalanced muscle protein turnover (i.e., protein breakdown exceeding synthesis), which in turn exacerbates other clinical conditions such as type 2 diabetes mellitus, obesity, osteoporosis, and cancer, thereby worsening the quality of life in older adults. This imbalance is attributed in part to the resistance of aged muscle to anabolic stimuli such as dietary protein/amino acids and resistance exercise known as anabolic resistance. Despite research efforts, no practical therapeutics have been successfully discovered possibly because of a lack of understanding of the dynamic nature of muscle protein, and the use of indirect assessments of muscle mass. Herein, we briefly discuss the regulation of protein turnover in response to the abovementioned anabolic stimuli with respect to anabolic resistance and optimal protein intake, followed by methodological considerations for advancing sarcopenia research, including assessments of muscle mass and dynamics.

키워드

Sarcopenia; Metabolism; Essential amino acids; Stable isotope labeling

원문 및 링크아웃 정보

등재저널 정보