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High Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy

Journal of Clinical Neurology 2020년 16권 4호 p.581 ~ 585
김은영, 이순태, 김영숙, 변자민, 홍준식, 신동엽, 고영일, 김인호,
소속 상세정보
김은영 ( Kim Eun-Young ) - Seoul National University Hospital Department of Neurology
이순태 ( Lee Soon-Tae ) - Seoul National University Hospital Department of Neurology
김영숙 ( Kim Young-Sook ) - Seoul National University Hospital Department of Neurology
변자민 ( Byun Ja-Min ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
홍준식 ( Hong Jun-Shik ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
신동엽 ( Shin Dong-Yeop ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
고영일 ( Koh Young-Il ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
김인호 ( Kim In-Ho ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine

Abstract


Background and Purpose: The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we analyzed the cfDNA level as a biomarker for LMSs in hematologic malignancy.

Methods: This study prospectively enrolled 20 patients with hematologic malignancy who underwent cerebrospinal fluid (CSF) analysis. LMS was diagnosed based on both CSF cytology and clinical findings.

Results: The CSF level of cfDNA was higher in patients with LMSs (108.17±84.84 ng/mL, mean±standard deviation) than in non-LMS patients (14.23±2.78 ng/mL). The sensitivity of cfDNA was higher than that of cytology (100% vs. 87%).

Conclusions: The cfDNA level in the CSF can be used as a supplemental marker for diagnosing LMS in hematologic malignancy patients.

키워드

leptomeningeal metastases; hematologic malignancy; cell-free DNA

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