잠시만 기다려 주세요. 로딩중입니다.

Causes, Risk Factors, and Clinical Outcomes of Stroke in Korean Young Adults: Systemic Lupus Erythematosus is Associated with Unfavorable Outcomes

Journal of Clinical Neurology 2020년 16권 4호 p.605 ~ 611
권혁성, 김영수, 이종민, 고성호, 김현영, 김철호, 이승훈, 김영대, 권형민, 김범준, 김정민, 김범준, 허성혁, 장대일,
소속 상세정보
권혁성 ( Kwon Hyuk-Sung ) - Hanyang University College of Medicine Department of Neurology
김영수 ( Kim Young-Seo ) - Hanyang University College of Medicine Department of Neurology
이종민 ( Lee Jong-Min ) - Hanyang University College of Medicine Department of Neurology
고성호 ( Koh Seong-Ho ) - Hanyang University College of Medicine Department of Neurology
김현영 ( Kim Hyun-Young ) - Hanyang University College of Medicine Department of Neurology
김철호 ( Kim Chul-Ho ) - Hallym University Sacred Heart Hospital Department of Neurology
이승훈 ( Lee Seung-Hoon ) - Seoul National University Hospital Department of Neurology
김영대 ( Kim Young-Dae ) - Yonsei University College of Medicine Department of Neurology
권형민 ( Kwon Hyung-Min ) - Seoul National University College of Medicine SMG-SNU Boramae Medical Center Department of Neurology
김범준 ( Kim Beom-Joon ) - Seoul National University Bundang Hospital Department of Neurology
김정민 ( Kim Jeong-Min ) - Chung-Ang University Hospital Department of Neurology
김범준 ( Kim Bum-Joon ) - University of Ulsan College of Medicine Asan Medical Center Department of Neurology
허성혁 ( Heo Sung-Hyuk ) - Kyung Hee University School of Medicine Department of Neurology
장대일 ( Chang Dae-Il ) - Kyung Hee University School of Medicine Department of Neurology

Abstract


Background and Purpose: The incidence of ischemic stroke (IS) in young adults is increasing, and the associated large socioeconomic impact makes understanding IS in young adults important. We investigated the causes of and risk factors for IS in young adults, and their impact on outcomes.

Methods: The Stroke in Korean Young Adults (SKY) study is a standardized multicenter prospective study involving eight medical centers of the Republic of Korea. First-ever IS patients aged 18 years to 44 years were prospectively included in this study within 7 days of stroke onset. Their outcomes at 3 months were analyzed.

Results: This study enrolled 270 patients from April 2014 to December 2018, most (67.8%) of whom were male. About 41.5% of the patients had one or more vascular risk factors from among hypertension, diabetes mellitus, and dyslipidemia. However, only half of them had received regular treatment. Arterial dissection was more common in males, and systemic lupus erythematosus (SLE) and Moyamoya disease were more common in females. The outcome was favorable (modified Rankin Scale score of 0 or 1) in 81.9% of the patients at 3 months after stroke onset. More severe initial symptoms, higher initial glucose level, and SLE as a comorbidity were associated with unfavorable outcomes.

Conclusions: Young adult IS patients in Korea exhibit low awareness and poor management of their risk factors. Although the short-term outcome was relatively favorable in those patients, having SLE was associated with unfavorable outcomes. More attention needs to be paid for improving awareness and controlling risk factors in this population.

키워드

ischemic stroke; young adults; outcome; systemic lupus erythematosus

원문 및 링크아웃 정보

등재저널 정보