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Tacrolimus for Treating Orbital and Cranial Form of Idiopathic Inflammatory Pseudotumors

Journal of Clinical Neurology 2020년 16권 4호 p.674 ~ 680
김현재, 이선경, 구유진, 권은진, 김효정, 최정윤, 김지수,
소속 상세정보
김현재 ( Kim Hyun-Jae ) - Seoul National University Bundang Hospital Department of Neurology
이선경 ( Lee Seon-Kyung ) - Seoul National University Bundang Hospital Department of Neurology
구유진 ( Koo Yu-Jin ) - Seoul National University Bundang Hospital Department of Neurology
권은진 ( Kwon Eun-Jin ) - Seoul National University Bundang Hospital Department of Neurology
김효정 ( Kim Hyo-Jung ) - Seoul National University Bundang Hospital Research Administration Team
최정윤 ( Choi Jeong-Yoon ) - Seoul National University Bundang Hospital Department of Neurology
김지수 ( Kim Ji-Soo ) - Seoul National University Bundang Hospital Department of Neurology

Abstract


Background and Purpose: Orbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always effective.

Methods: We reviewed the medical records of three patients with orbital or cranial form of IIP who were treated with tacrolimus as an adjuvant treatment.

Results: The three patients showed favorable outcomes with the addition of tacrolimus, which is a calcineurin inhibitor that inhibits T-cell activation and T-cell-dependent B-cell activation.

Conclusions: Tacrolimus may be a safe and effective immunosuppressant for refractory or relapsing form of orbital or cranial IIPs.

키워드

tacrolimus; inflammatory pseudotumor; Tolosa-Hunt syndrome; orbital pseudotumor

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