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일교차가 당뇨병성 창상의 치유에 미치는 영향: 동물 실험 연구

Relationship between the Diurnal Temperature Range and Wound Healing of Diabetic Foot: Animal Study

대한족부족관절학회지 2020년 24권 4호 p.142 ~ 147
원성훈, 천동일, 조재호, 박인근, 이영,
소속 상세정보
원성훈 ( Won Sung-Hun ) - Soonchunhyang University Seoul Hospital Department of Orthopedic Surgery
천동일 ( Chun Dong-Il ) - Soonchunhyang University Seoul Hospital Department of Orthopedic Surgery
조재호 ( Cho Jae-Ho ) - Hallym University Chuncheon Sacred Heart Hospital Department of Orthopedic Surgery
박인근 ( Park In-Keun ) - Inje University Seoul Paik Hospital Department of Orthopedic Surgery
이영 ( Yi Young ) - Inje University College of Medicine Seoul Paik Hospital Department of Orthopaedic Surgery

Abstract


Purpose: Diabetic foot ulcers are closely related to body surface heat, which can be affected easily by temperature differences. This study examined the correlation between the healing process of diabetic wounds and abnormal diurnal temperature through an animal study.

Materials and Methods: Rats in the abnormal diurnal temperature group and control group were given a 10 mm sized full-thickness skin ulcer. Wound size progression was observed in both groups. H&E and Masson’s trichrome staining was performed at 14 days after wound formation, and the number of vessels per unit area and histology analysis were performed. The changes in the ulcer were mea?sured through three dimensional cross-section area using INSIGHT® devices.

Results: The wound recovery period (granulation ingrowing) was 24 days in the abnormal diurnal temperature model and 20 days in the control group. The thickness of scar tissue was 402±23.19 μm in the control group and 424.5±36.94 μm in the diurnal temperature model. Neovascular formation was counted as 5.1±0.97 for the control group and 4.16±0.94 for the diurnal temperature model group.

Conclusion: Delayed and inferior diabetic wound healing was observed in the abnormal diurnal temperature group, which was charac?terized by greater diurnal variations than the typical growth environment.

키워드

Diabetic foot; Amputation; Animal study; Temperature; Wound healing

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