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자소엽 주정 추출물이 고지방식이로 유도된 대사증후군 및 비알코올성 지방간 개선에 미치는 영향

Effects of the Perilla frutescens Britton var. acuta Kudo Ethanol Extract (PFE) on the Improvement of Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease Induced by High-Fat Diet

한국식품영양과학회지 2020년 49권 10호 p.1045 ~ 1053
최지영, 김지원, 권은영,
소속 상세정보
최지영 ( Choi Ji-Young ) - Chosun University Department of Food and Nutrition
김지원 ( Kim Ji-Won ) - Kyungpook National University Department of Food and Nutrition
권은영 ( Kwon Eun-Young ) - Kyungpook National University Department of Food and Nutrition

Abstract


Perilla frutescens Britton var. acuta Kudo (PF) is a traditional herb that belongs to the lamiaceae family. PF has been reported to have numerous biological activities, including antioxidant, anti-allergic, anti-inflammatory, anticancer, and neuroprotection effects. This study examined the effects of PF ethanol extract (PFE) on obesity and its complications, particularly focusing on non-alcoholic fatty liver disease (NAFLD) in C57BL/6J mice fed high-fat diets (HFD). Male mice were fed a normal diet (ND), a HFD, or HFD+PFE (1% w/w, PFE) for 12 weeks. The PFE treatment ameliorated dyslipidemia and hyperglycemia HFD-induced obese mice coupled with the enhanced energy expenditure. The liver weight and hepatic lipotoxicity markers (GOT and GPT) were reduced significantly in the PFE group than in the HFD group. Moreover, the hepatic lipid profiles and morphological analysis showed less hepatic lipid accumulation in the PFE group than the HFD-fed mice. In particular, the expression of hepatic lipogenic genes (Acc1 and Cidea) was down-regulated, whereas the expression of fatty acid oxidation-related genes (Pgc1α and Pparα) was increased. These results suggest that PFE can prevent or attenuate the development of HFD-induced obesity and NAFLD.

키워드

Perilla frutescens Britton var. acuta Kudo ethanol extract; high-fat diet-induced obesity; non-alcoholic fatty liver disease, energy expenditure; hypolipidemic effect

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