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Evaluation Potential Antidiabetic Effects of Ferula latisecta in Streptozotocin-Induced Diabetic Rats

대한약침학회지 2020년 23권 3호 p.158 ~ 164
Javanshir Sajad, Soukhtanloo Mohammad, Jalili-Nik Mohammad, Yazdi Amirali Jahani, Amiri Mohammad Sadegh, Ghorbani Ahmad,
소속 상세정보
 ( Javanshir Sajad ) - Mashhad University of Medical Sciences School of Dentistry Student Research Committee
 ( Soukhtanloo Mohammad ) - Mashhad University of Medical Sciences Faculty of Medicine Department of Clinical Biochemistry
 ( Jalili-Nik Mohammad ) - Mashhad University of Medical Sciences Faculty of Medicine Department of Clinical Biochemistry
 ( Yazdi Amirali Jahani ) - Mashhad University of Medical Sciences School of Paramedical Sciences Department of Laboratory Sciences
 ( Amiri Mohammad Sadegh ) - Payame Noor University Department of Biology
 ( Ghorbani Ahmad ) - Mashhad University of Medical Sciences Pharmacological Research Center of Medicinal Plants

Abstract


Objectives: The aim of the present work was to evaluate the possible beneficial effects of F.
latisecta on blood glucose, lipids, and diabetes-related changes in the liver and kidney of streptozotocin-induced diabetic rats.

Methods: Male Wistar rats were randomly allocated into four groups (n = 6): normal control rats, diabetic control rats, diabetic rats treated for 4 weeks with F. latisecta root (400 mg/kg/day), and diabetic rats treated with F. latisecta aerial parts (400 mg/kg/day).

Results: Induction of diabetes significantly (p < 0.05) increased the levels of fasting blood glucose (FBG), triglyceride, total cholesterol, low-density lipoprotein (LDL), blood urea nitrogen (BUN), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Diabetes also increased (p < 0.05) oxidative stress in the kidney and liver (decrease of thiol and increase of superoxide dismutase). The root and aerial parts of F. latisecta significantly reduced the level of LDL (p < 0.05) and restored the content of thiol (p < 0.05) and superoxide dismutase (p < 0.01) in the kidney and liver. F. latisecta had no significant effect on the levels of FBG, BUN, AST, and ALT. The root of F. latisecta also reduced the serum level of total cholesterol (p < 0.05) and prevented the progression of hyperglycemia.

Conclusion: These findings suggest that F. latisecta may improve diabetic dyslipidemia by reducing serum LDL. Further studies are needed to confirm our findings.

키워드

diabetes; Ferula; glucose; lipids; oxidative stress

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