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Green Synthesis to Develop Iron-Nano Formulations and Its Toxicity Assays

대한약침학회지 2020년 23권 3호 p.165 ~ 172
Kulkarni Smital, Mohanty Nimain, Kadam Nitin N., Swain Niharika, Thakur Mansee,
소속 상세정보
 ( Kulkarni Smital ) - MGMIHS MGMSBS Department of Medical Biotechnology
 ( Mohanty Nimain ) - MGMIHS MGM Medical College Department of Pediatrics
 ( Kadam Nitin N. ) - MGMIHS MGM Medical College Department of Pediatrics
 ( Swain Niharika ) - MGM Dental College and Hospital Department of Oral Pathology
 ( Thakur Mansee ) - MGMIHS MGMSBS and CRL Department of Medical Biotechnology

Abstract


Objectives: In the past few years, herbal medicines have gained popularity over synthetic drugs because of their natural source and minimal side effects which has led to a tremendous growth of phytopharmaceuticals usage. With the development of nanotechnology, it provides alternative approaches to overcome several limitations using nano-formulations. In spite of considerable quantity of antianemic preparations with different iron forms available, currently additives are used and represented in modern pharmaceutical market. Iron deficiency anemia is a major global public health problem which particularly affects pregnant women, children and elderly persons. The situation is complicated because of disadvantages and drug side effects from existing antianemic medicines. There is a great demand for the development of new antianemic preparations. Green synthesis of iron oxide nanoparticles, possess high potential in this field.

Methods: Our study focuses on developing green synthesis of iron oxide nanoparticles (IONPs) of 10-50 nm with spherical shape where different dosages were used ?1 mg/kg, 10 mg/kg and 100 mg/kg for exposure in Wistar albino female rats for 28 days. The toxicity was assessed using various parameters such as measurements of the rat body and organ mass, hematology, biochemical evaluation and histopathological examinations.

Results: No significant differences were observed in body and organ weights. Hematological indices also indicated no significant differences whereas biochemical factors showed increase in levels of direct bilirubin and globulin of medium as well as high dose and SGPT levels were increased only in high dose. The major organs (heart, kidney and liver) showed histopathological alterations in 10 and 100 mg/kg whereas brain showed only in 100 mg/kg.

Conclusion: The toxicity of IONPs was found to be more significant when the concentration was increased; however, low doses can be used for further investigation as an antianemic preparation.

키워드

iron oxide nanoparticles; biosafety; antianemic preparation

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