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Comparing the Therapeutic Effects of Aloe vera and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial

대한약침학회지 2020년 23권 3호 p.173 ~ 178
Panahi Yunes, Rastga Nassim, Zamani Ali, Sahebkar Amirhossein,
소속 상세정보
 ( Panahi Yunes ) - Baqiyatallah University of Medical Sciences Faculty of Pharmacy Pharmacotherapy Department
 ( Rastga Nassim ) - Islamic Azad University Faculty of Pharmacy Department of Pharmaceutics
 ( Zamani Ali ) - Baqiyatallah University of Medical Sciences Faculty of Pharmacy Pharmacotherapy Department
 ( Sahebkar Amirhossein ) - Mashhad University of Medical Sciences Neurogenic Inflammation Research Center

Abstract


Objectives: Atopic dermatitis (AD) is a prevalent and chronic, pruritic inflammatory skin condition that can influence all age groups. AD is associated with a poor health-related quality of life. This randomized clinical trial was performed to compare the effectiveness of Olivederma (combination of aloe vera and virgin olive oil) or betamethasone regarding disease severity, quality of life, serum IgE and eosinophil count.

Methods: Thirty-six AD patients were randomly allocated to topical Olivederma or betamethasone, and were followed for 6 weeks.

Results: Total SCORAD severity scores showed significant decrease in both groups, while it was more prominent in Olivederma group (64.5% improvement in Olivederma vs. 13.5% improvement in Betamethasone, p-value < 0.001). Quality of life (DLQI questionnaire) of AD patients was significantly improved after 6 weeks treatment with Betamethasone (22.3%, p < 0.001) and Olivederma (60.7%, p-value < 0.001). Olivederma group showed a significantly lower DLQI score in comparison with Betamethasone treated patients after 6 weeks of therapy (p < 0.001). Improvements in eosinophil count and serum IgE was observed.

Conclusion: In summary, this study shows that Olivederma is superior to topical Betamethasone after 6 weeks of therapy with regard to disease severity, quality of life and eosinophil count.

키워드

atopic dermatitis; Aloe vera; olive oil; corticosteroid; topical administration

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