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Free gait in a shallow pool accelerates recovery after exercise in model mice with fibromyalgia

Journal of Exercise Rehabilitation 2020년 16권 5호 p.398 ~ 409
Nakata Taiki, Doi Atsushi, Uta Daisuke, 신민철, Yoshimura Megumu,
소속 상세정보
 ( Nakata Taiki ) - Kumamoto-Saiseikai Hospital Department of Rehabilitation
 ( Doi Atsushi ) - Kumamoto Health Science University Graduate School of Health Science
 ( Uta Daisuke ) - University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Department of Applied Pharmacology
신민철 ( Shin Min-Chul ) - Kumamoto Health Science University Graduate School of Health Science
 ( Yoshimura Megumu ) - Nakamura Hospital Department of Orthopedic Surgery

Abstract


This study aimed to determine the effect of pool gait exercise using fibromyalgia-induced model mice. The sensory threshold, locomotive behavior, electrocardiogram, and onset time after the gait test in shallow water using male C57BL/6J mice (weight, 30?35 g; n= 21) were investigated. To induce fibromyalgia in model mice, reserpine was injected intraperitoneally into wild-type mice once a day for 3 days. Subsequently, the fibromyalgia-induced model mice were randomly classified into two groups as follows: the control group (n= 11) and the pool gait group (n= 10). The mice in the pool gait group walked in the same cage containing shallow warm water 5 times per week. Both groups underwent sensory thresholds and video recordings to determine locomotive behaviors weekly. Further, both heart rate and video recordings for observation of a recovery after the gait test in shallow water were undertaken (control group; n= 5, pool gait group; n= 5). The pool gait did not affect sensory thresholds and locomotive behavior; however, in the pool gait group, both the recovery after the test, such as onset time and gait distance, were considerably better than those of the control group. Furthermore, changes in heart rate and heart rate irregularity after the test were more apparent in the control group than in the pool gait group. The free gait in a shallow pool accelerated recovery after exercise, unlike the sensory threshold.

키워드

Shallow pool gait; Behavior analysis; Fibromyalgia-induced model mouse

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