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In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench

Endocrinology and Metabolism 2020년 35권 4호 p.733 ~ 749
김일영, 박상희, 김영민, 장예원, 최철수, 서상훈, Wolfe Robert R.,
소속 상세정보
김일영 ( Kim Il-Young ) - Gachon University College of Medicine Department of Molecular Medicine
박상희 ( Park Sang-Hee ) - Gachon University Lee Gil Ya Cancer and Diabetes Institute Korea Mouse Metabolic Phenotyping Center (KMMPC)
김영민 ( Kim Yeong-Min ) - Gachon University Gachon Advanced Institute for Health Sciences and Technology Department of Health Sciences and Technology
장예원 ( Chang Ye-Won ) - Gachon University Gachon Advanced Institute for Health Sciences and Technology Department of Health Sciences and Technology
최철수 ( Choi Cheol-Soo ) - Gachon University Lee Gil Ya Cancer and Diabetes Institute Korea Mouse Metabolic Phenotyping Center (KMMPC)
서상훈 ( Suh Sang-Hoon ) - Yonsei University Department of Physical Education
 ( Wolfe Robert R. ) - University of Arkansas for Medical Sciences Department of Geriatrics

Abstract


Like other substrates, plasma glucose is in a dynamic state of constant turnover (i.e., rates of glucose appearance [Ra glucose] into and disappearance [Rd glucose] from the plasma) while staying within a narrow range of normal concentrations, a physiological priority. Persistent imbalance of glucose turnover leads to elevations (i.e., hyperglycemia, Ra>Rd) or falls (i.e., hypoglycemia, Ra

키워드

Stable isotope tracers; Metabolic fluxomics; Insulin resistance; Diabetes mellitus

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