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Mothership versus Drip-and-Ship Model for Mechanical Thrombectomy in Acute Stroke: A Systematic Review and Meta-Analysis for Clinical and Radiological Outcomes

Journal of Stroke 2020년 22권 3호 p.317 ~ 323
Romoli Michele, Paciaroni Maurizio, Tsivgoulis Georgios, Agostoni Elio Clemente, Vidale Simone,
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 ( Romoli Michele ) - AUSL Romagna Rimini Infermi Hospital Neurology Unit
 ( Paciaroni Maurizio ) - University of Perugia Santa Maria della Misericordia Hospital Stroke Unit
 ( Tsivgoulis Georgios ) - National and Kapodistrian University of Athens School of Medicine Attikon Hospital Second Department of Neurology
 ( Agostoni Elio Clemente ) - Niguarda Ca’ Granda Hospital Department of Neurology
 ( Vidale Simone ) - AUSL Romagna Rimini Infermi Hospital Neurology Unit

Abstract


Background and Purpose: Substantial uncertainty exists on the benefit of organizational paradigms in stroke networks. Here we systematically reviewed and meta-analyzed data from studies comparing functional outcome between the mothership (MS) and the drip and ship (DS) models.

Methods: The meta-analysis protocol was registered international prospective register of systematic reviews (PROSPERO) and followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, and Cochrane Central databases were searched for randomized-controlled clinical trials (RCTs), retrospective and prospective studies comparing MS versus DS. Primary endpoints were functional independence at 90 days (modified Rankin Scale <3) and successful recanalization (Thrombolysis in Cerebral Infarction Scale [TICI] >2a); secondary endpoints were 3-month mortality and symptomatic intracranial haemorrhage (sICH). Odds ratios for endpoints were pooled using the random effects model and were compared between the two organizational models.

Results: Overall, 18 studies (n=7,017) were included in quantitative synthesis. MS paradigm was superior to DS model for functional independence (odds ratio, 1.34; 95% confidence interval, 1.16 to 1.55; I2=30%). Meta-regression analysis revealed association between onset-to-needle time and good functional outcome, with longer onset-to-needle time being detrimental. Similar rates of recanalization, sICH and mortality at 90 days were documented between MS and DS.

Conclusions: Patients with acute ischemic stroke eligible for reperfusion strategies might benefit more from MS paradigm as compared to DS. RCTs are needed to further refine best management taking into account logistics, facilities and resources.

키워드

Stroke; Mothership; Drip and ship; Thrombectomy; Endovascular procedures

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