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Freeform 3D printing of soft matters: recent advances in technology for biomedical engineering

Biomedical Engineering Letters 2020년 10권 4호 p.453 ~ 479
Chen Shengyang, Tan Wen See, Juhari Muhammad Aidil Bin, Shi Qian, Cheng Xue Shirley, Chan Wai Lee, 송주하,
소속 상세정보
 ( Chen Shengyang ) - Nanyang Technological University School of Chemical and Biological Engineering
 ( Tan Wen See ) - Nanyang Technological University School of Chemical and Biological Engineering
 ( Juhari Muhammad Aidil Bin ) - Nanyang Technological University School of Chemical and Biological Engineering
 ( Shi Qian ) - Nanyang Technological University School of Chemical and Biological Engineering
 ( Cheng Xue Shirley ) - Nanyang Technological University School of Chemical and Biological Engineering
 ( Chan Wai Lee ) - Nanyang Technological University School of Chemical and Biological Engineering
송주하 ( Song Ju-Ha ) - Nanyang Technological University School of Chemical and Biological Engineering

Abstract


In the last decade, an emerging three-dimensional (3D) printing technique named freeform 3D printing has revolutionized the biomedical engineering field by allowing soft matters with or without cells to be printed and solidified with high precision regardless of their poor self-supportability. The key to this freeform 3D printing technology is the supporting matrices that hold the printed soft ink materials during omnidirectional writing and solidification. This approach not only overcomes structural design restrictions of conventional layer-by-layer printing but also helps to realize 3D printing of low-viscosity or slow-curing materials. This article focuses on the recent developments in freeform 3D printing of soft matters such as hydrogels, cells, and silicone elastomers, for biomedical engineering. Herein, we classify the reported freeform 3D printing systems into positive, negative, and functional based on the fabrication process, and discuss the rheological requirements of the supporting matrix in accordance with the rheological behavior of counterpart inks, aiming to guide development and evaluation of new freeform printing systems. We also provide a brief overview of various material systems used as supporting matrices for freeform 3D printing systems and explore the potential applications of freeform 3D printing systems in different areas of biomedical engineering.

키워드

Additive manufacturing; Freeform 3D printing; Supporting matrix; Soft matters; Biomedical engineering

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