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Control strategy with multivariable fault tolerance module for automatic intravenous anesthesia

Biomedical Engineering Letters 2020년 10권 4호 p.555 ~ 578
Patel Bhavina, Patel Hirenkumar, Shah Divyang, Sarvaia Alpesh,
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 ( Patel Bhavina ) - Sardar Vallabhbhai National Institute of Technology Department of Electrical Engineering
 ( Patel Hirenkumar ) - Sardar Vallabhbhai National Institute of Technology Department of Electrical Engineering
 ( Shah Divyang ) - Surat Municipal Institute of Medical Education and Research
 ( Sarvaia Alpesh ) - U. N. Mehta Institute of Cardiology and Research

Abstract


In the anesthesia automation, an automatic propofol infusion system uses Bi-spectral Index Signal (BIS) as a primary feedback signal to manipulate propofol dose. However, the BIS signal may be suspended for some time due to poor EEG signal quality, noise, and many other factors. Therefore, BIS signal failure may be the main cause of inadequate propofol infusion. This fact motivates the need for integration of multivariable fault tolerance module (MFTM) and fractional-order Smith predictor controller to avoid adverse reactions of inadequate propofol dosing during BIS failure. Smith Predictor control strategy is sufficiently robust to predict feedback BIS during BIS failure via patient pharmacological modeled BIS. However, modeled BIS may not provide a guarantee of adequate propofol infusion during BIS failure and especially in the presence of hypotension and hypertension. Thus, the proposed control strategy is designed with MFTM to detect BIS sensor fault and to estimate feedback BIS during BIS failure. Further, the proposed control strategy is designed with a multivariable pharmacological patient model to analyze the cross effect of propofol infusion on BIS and hemodynamic variables. The robustness of the proposed control strategy is tested in the presence of noxious surgical stimulation, BIS sensor fault and heavy hemodynamic disturbance. The pharmacological parameters and recorded signals of 30 patients during various surgeries have been used to validate simulated results. The performance of the proposed control strategy assures optimization and smooth propofol infusion during BIS failure. The proposed system provides stability for a wide range of physiological parameters range. The proposed scheme maintains smooth BIS and MAP signal despite the delay, BIS sensor fault, and surgical disturbances.

키워드

Multivariable fault tolerance module (MFTM); Propofol; Bi-spectral Index Signal (BIS); Mean arterial pressure (MAP); Depth of anesthesia (DOA)

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