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Risk factors for intensive care unit admission and mortality in hospitalized COVID-19 patients

Acute and Critical Care 2020년 35권 4호 p.249 ~ 254
Ayaz Ahmed, Arshad Ainan, Malik Hajra, Ali Haris, Hussain Erfan, Jamil Bushra,
소속 상세정보
 ( Ayaz Ahmed ) - Aga Khan University Medical College
 ( Arshad Ainan ) - Aga Khan University Department of Internal Medicine
 ( Malik Hajra ) - Aga Khan University Medical College
 ( Ali Haris ) - Aga Khan University Medical College
 ( Hussain Erfan ) - Aga Khan University Department of Pulmonary and Critical Care
 ( Jamil Bushra ) - Aga Khan University Department of Infectious Diseases

Abstract


Background: This study investigated the clinical features and outcome of hospitalized coronavirus disease 2019 (COVID-19) patients admitted to our quaternary care hospital.

Methods: In this retrospective cohort study, we included all adult patients with COVID-19 infection admitted to a quaternary care hospital in Pakistan from March 1 to April 15, 2020. The extracted variables included demographics, comorbidities, presenting symptoms, laboratory tests and radiological findings during admission. Outcome measures included in-hospital mortality and length of stay.

Results: Sixty-six COVID-19 patients were hospitalized during the study period. Sixty-one percent were male and 39% female; mean age was 50.6±19.1 years. Fever and cough were the most common presenting symptoms. Serial chest X-rays showed bilateral pulmonary opacities in 33 (50%) patients. The overall mortality was 14% and mean length of stay was 8.4±8.9 days. Ten patients (15%) required intensive care unit (ICU) care during admission, of which six (9%) were intubated. Age ≥60 years, diabetes, ischemic heart disease, ICU admission, neutrophil to lymphocyte ratio ≥3.3, and international normalized ratio ≥1.2 were associated with increased risk of mortality.

Conclusions: We found a mortality rate of 14% in hospitalized COVID-19 patients. COVID-19 cases are still increasing exponentially around the world and may overwhelm healthcare systems in many countries soon. Our findings can be used for early identification of patients who may require intensive care and aggressive management in order to improve outcomes.

키워드

COVID-19; critical illness; outcomes assessment

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