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Current Status of the Research and Development of Bispecific Antibodies

Biomedical Science Letters 2020년 26권 3호 p.136 ~ 148
권순일,
소속 상세정보
권순일 ( Kwon Sun-Il ) - Deagu Health Science University Department of Biomedical Laboratory Science

Abstract


A bispecific antibody (BsAb) is an artificial protein containing two kinds of specific antigen binding sites. BsAb can connect target cells to functional cells or molecules, and thus stimulate a directed immune response. Last several decades a wide variety of bsAb formats and production technologies have been developed. BsAbs are constructed either chemically or biologically, exploiting techniques like cell fusion and recombinant DNA technologies. There are over 100 different formats of bsAb so far developed, but they could be classified into the two main categories such as Fc-based (with a Fc region) bsAbs and fragment-based (without a Fc region) bsAbs. BsAb has a broad application prospect in tumor immunotherapy and drug delivery. Here, we present a brief introduction to the structure of antibody, pharmacological mechanisms of antibodies and the trend in the production technologies of therapeutic antibodies. In addition, we address a review on the current status of various bsAb format development and their production technologies together with global situation in the clinical studies of bsAb.

키워드

Antibody; Anticancer; Bispecific; bsAb; Format; Immunotherapy

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