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Antioxidant Effect of Mulberry Leaves and Yacon Tuber Extracts in High-fat Diet-fed Rats

Biomedical Science Letters 2020년 26권 3호 p.201 ~ 209
김광진, 임용, 오지혜, 박언규, 허만규, 황석연,
소속 상세정보
김광진 ( Kim Kwang-Jin ) - Ministry of Food and Drug Safety National Institute of Food and Drug Safety Evaluation
임용 ( Lim Yong ) - Dong-Eui University Department of Clinical Laboratory Science
오지혜 ( Oh Ji-Hye ) - Daejeon University Department of Biomedical Laboratory Science
박언규 ( Park Un-Kyu ) - Daejeon University Department of Biomedical Laboratory Science
허만규 ( Huh Man-Kyu ) - Dong-Eui University Food Engineering and Technology Major
황석연 ( Hwang Seock-Yeon ) - Daejeon University Department of Biomedical Laboratory Science

Abstract


The effect of mulberry leaves and yacon tuber extracts (MYE) on antioxidant was tested in this study. The present study investigated the in vivo effects of the anti-oxidative effect of MYE on catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px), and thiobarbituric acid reactive substances (TBARS). The seven-day acclimation of the mice was divided into six groups: Normal diet group (NOR), high fat diet group (HFD), high fat diet with 0.5% hydroxycitric acid group diet group for positive group (HHCA), high fat diet with 1% mulberry leaf and 1% yacon diet group (MYE-1), high fat diet with 3% mulberry leaf and 3% yacon group (MYE-3) and high fat diet with 5% mulberry leaf and 5% yacon group (MYE-5). The effect of serum antioxidant in the catalase of MYE-1, MYE-3, and HHCA comparing to HFD by 31.0%, 27.7% and 45.2%, respectively (P<0.05~0.01). The effect on hepatic antioxidant in the catalase of HFD was significantly increased 3.7 (77.3%) times than that of NOR (P<0.01). But, the activities of catalase were decreased significantly in MYE-1, MYE-3, MYE-5 and HHCA by 21.7%, 24.2%, 24.9%, and 28.8% compared to HFD, respectively. GSH-Px was significantly decreased in MYE-1, MYE-3, MYE-5 and HHCA by 15.5%, 37.1%, 23.4%, and 23.7% compared to HFD, respectively (P<0.05). The activities of CAT, SOD, GST, GSH-Px, and TBARS were more significantly decreased in MYE-1 and MYE-3 than those of HFD and HHCA. MYE have shown significant effects on anti-oxidative function against high fat diet.

키워드

Antioxidant; Catalase (CAT); Glutathione S-transferase (GST); Mulberry leaves; Yacon tuber

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